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Overdosage
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness, or se
izures.
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Description
Acyclovir is used to treat herpes infections of the skin, lip, and genitals; herpes zoster (shingles); and chickenpox. It does not cure herpes infections but decreases pain and itching and promotes he
aling.
Topical acyclovir does not prevent the recurrence of sores but may decrease pain and itching if applied when the earliest symptoms first appear. Oral acyclovir decreases the frequency
and severity of recurrent sores, but it is used only by people with severe herpes infections because of possible adverse effects.
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Precautions while Using this Medicine
Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This medicine is excreted in breast milk.
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Side Effects
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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What special precautions should I follow?
Other medicines¡XAlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your do
or may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other topical prescription or nonprescription (over-the-counter [OTC]) me
dicine that is to be applied to the same area of the skin.
Other medical problems¡XTell your doctor if your herpes simplex infection keeps coming back while you are using acyclovir
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Possible food and drug interactions when taking this medication
It is especially important that your health care professional know if you are taking any of the following:
- Carmustine (e.g., BiCNU) or
- Cisplatin (e.g., Platinol) or
- Combination pa
in medicine containing acetaminophen and aspirin (e.g., Excedrin) or other salicylates or
- Cyclosporine (e.g., Sandimmune) or
- Deferoxamine (e.g., Desferal) (with long-term use) or
-
Gold salts (medicine for arthritis) or
- Inflammation or pain medicine, except narcotics, or
- Lithium (e.g., Lithane) or
- Methotrexate (Mexate) or
- Other medicine for infection
or
- Penicillamine (e.g., Cuprimine) or
- Plicamycin (e.g., Mithracin) or
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