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Missing Dose
If you are using tablets, capsules, or liquid, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals.
If you are using ointment,
apply it as soon as you remember and apply further doses at your regular interval (e.g., every 3 hours) until you go to bed.
However, if it is almost time for the next dose, skip the missed
dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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Why is this drug prescribed?
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although not specifically included in product labeling, acyclo
vir by injection is used in certain patients with the following medical conditions:
Herpes simplex (for prevention of repeated infections) in people with a weak immune system
Herpes zos
ter infections of the eye
Shingles (for prevention of repeated infections) in people with a weak immune system
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Symptoms of overdose may include:
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness, or se
izures.
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Drug Interactions
Inform your doctor if you are taking any of the following:
- Lithium (e.g., Lithane) or
- Methotrexate or
- Other medicine for infection or
- Penicillamine (e.g., Cuprimine)
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What side effects can this medication cause?
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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Precautions while Using this Medicine
Category C. Risk to fetus cannot be ruled out. Consider use if benefit outweighs the potential risk. Exposure registry is available: 1-800-722-9292, ext. 58465 (note: this number is no longer used for
antiretroviral drugs. See Health Maintenance section for the pregnancy protocols which contain the antiretroviral registry number.)
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