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Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness, or se
izures.
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What side effects can this medication cause?
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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What special precautions should I follow?
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
The areas affected by herpes, chickenpox, or shingles should be kept as clean and dry as po
ssible. Also, wear loose-fitting clothing to avoid irritating the sores (blisters).
It is important to remember that acyclovir will not keep you from spreading herpes to others.
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Possible food and drug interactions when taking this medication
It is especially important that your health care professional know if you are taking any of the following:
- Carmustine (e.g., BiCNU) or
- Cisplatin (e.g., Platinol) or
- Combination pa
in medicine containing acetaminophen and aspirin (e.g., Excedrin) or other salicylates or
- Cyclosporine (e.g., Sandimmune) or
- Deferoxamine (e.g., Desferal) (with long-term use) or
-
Gold salts (medicine for arthritis) or
- Inflammation or pain medicine, except narcotics, or
- Lithium (e.g., Lithane) or
- Methotrexate (Mexate) or
- Other medicine for infection
or
- Penicillamine (e.g., Cuprimine) or
- Plicamycin (e.g., Mithracin) or
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Description
Acyclovir is used to treat herpes infections of the skin, lip, and genitals; herpes zoster (shingles); and chickenpox. It does not cure herpes infections but decreases pain and itching and promotes he
aling.
Topical acyclovir does not prevent the recurrence of sores but may decrease pain and itching if applied when the earliest symptoms first appear. Oral acyclovir decreases the frequency
and severity of recurrent sores, but it is used only by people with severe herpes infections because of possible adverse effects.
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What special precautions should I follow?
If you are or will be breast-feeing while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby.
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