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Other Medicines
It is especially important that your health care professional know if you are taking any of the following:
- Carmustine (e.g., BiCNU) or
- Cisplatin (e.g., Platinol) or
- Combination pa
in medicine containing acetaminophen and aspirin (e.g., Excedrin) or other salicylates or
- Cyclosporine (e.g., Sandimmune) or
- Deferoxamine (e.g., Desferal) (with long-term use) or
-
Gold salts (medicine for arthritis) or
- Inflammation or pain medicine, except narcotics, or
- Lithium (e.g., Lithane) or
- Methotrexate (Mexate) or
- Other medicine for infection
or
- Penicillamine (e.g., Cuprimine) or
- Plicamycin (e.g., Mithracin) or
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Side Effects of This Medicine
Parenteral:
1. Renal toxicity; precipitation of acyclovir crystals can occur in renal tubules if the maximum solubility of free acyclovir (2.5mg/ml at 37?C in water) is exceeded or if the drug is
given by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV acyclovir manifested encephalopath
ic changes characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; h
ematuria; hypotension; headache and nausea; thrombocytosis.
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Special warnings about this medication
Before taking acyclovir,
- tell your doctor and pharmacist if you are allergic to acyclovir, valacyclovir (Valtrex), or any other drugs.
- tell your doctor and pharmacist what prescripti
on and nonprescription medications you are taking, especially probenecid (Benemid), zidovudine (Retrovir, AZT), and vitamins.
- tell your doctor if you have or have ever had kidney disease, probl
ems with your immune system, human immunodeficiency virus infection (HIV), or acquired immunodeficiency syndrome (AIDS).
- tell your doctor if you are pregnant, plan to become pregnant, or are br
east-feeding. If you become pregnant while taking acyclovir, call your doctor.
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Symptoms of overdose
Symptoms of overdose may include sluggishness, change in amount of urine, loss of consciousness ¡K
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What should I do if I forget a dose?
Iit is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.
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What Is It
Acyclovir is used to treat herpes infections of the skin, lip, and genitals; herpes zoster (shingles); and chickenpox. It does not cure herpes infections but decreases pain and itching and promotes he
aling.
Topical acyclovir does not prevent the recurrence of sores but may decrease pain and itching if applied when the earliest symptoms first appear. Oral acyclovir decreases the frequency
and severity of recurrent sores, but it is used only by people with severe herpes infections because of possible adverse effects.
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