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Overdosage
Any medication taken in excess can have serious consequences. If you suspect an overdose of BuSpar, seek medical attention immediately.
The symptoms of BuSpar overdose may include:
- Di
zziness, drowsiness, nausea or vomiting, severe stomach upset, unusually small pupils.
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DRUG ABUSE AND DEPENDENCE :
When you are taking buspirone, it is especially important that your health care professional know if you are taking any of the following:
- Erythromycin (e.g., ERYC, E.E.S.) or
- Itraco
nazole (e.g., Sporanox)¡XHigher blood levels of buspirone may occur, increasing the chance of side effects. Your doctor may change the dose of buspirone that you take
- Monoamine oxidase (MAO) i
ibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline at doses more than 10 mg a day [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X
aking buspirone while you are taking monoamine oxidase (MAO) inhibitors may cause high blood pressure
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Why is this drug prescribed?
The mechanism of action of BUSPAR is not clearly known. BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relax
ant effects. It also lacks the prominent sedative effect that is associated with benzodiazepines
In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors
in the brain that mediate arousal). BUSPAR has no significant affinity for benzodiazepine receptors in the brain.
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Side Effects
Although side effects from buspirone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness
- upset stomach
- vomiting
- constipation
- diarrhea
- stomach pain
- headache
- dry mouth
- depression
- excitement
- fatigue
- nervousness
- difficulty sleeping
- lighth
eadedness
- weakness
- numbness
If you experience any of the following symptoms, call your doctor immediately:
- skin rash
- itching
- fast or irregular heartbe
at
- blurred vision
- unusual movements or the head or neck muscles
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Possible food and drug interactions when taking this medication
There is 1 report suggesting that the concomitant use of trazodone and buspirone may have caused 3- to 6-fold elevations in ALT (SGPT) in a few patients. In a similar study, attempting to replicate th
is finding, no interactive effect on hepatic transaminases was identified.
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Precautions
Possible Concerns Related to Buspirone's Binding to Dopamine Receptors:
Because buspirone can bind to central dopamine receptors, a question has been raised about its potential to cause acute and
chronic changes in dopamine mediated neurological function (e.g., dystonia, pseudoparkinsonism, akathisia, and tardive dyskinesia). Clinical experience in controlled trials has failed to identify any
significant neuroleptic-like activity; however, a syndrome of restlessness, appearing shortly after initiation of treatment, has been reported in some small fraction of buspirone treated patients. The
syndrome may be explained in several ways.
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