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DRUG ABUSE AND DEPENDENCE :
When you are taking buspirone, it is especially important that your health care professional know if you are taking any of the following:
- Erythromycin (e.g., ERYC, E.E.S.) or
- Itraco
nazole (e.g., Sporanox)ˇXHigher blood levels of buspirone may occur, increasing the chance of side effects. Your doctor may change the dose of buspirone that you take
- Monoamine oxidase (MAO) i
ibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline at doses more than 10 mg a day [e.g., Eldepryl], tranylcypromine [e.g., Parnate])ˇX
aking buspirone while you are taking monoamine oxidase (MAO) inhibitors may cause high blood pressure
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Adverse Effects
Post Introduction Clinical Experience:
Post-marketing experience in the US has shown an adverse experience profile similar to that given above. Additional reports have included rare occurrences of
allergic reaction, cogwheel rigidity, dystonic reaction, ecchymosis, emotional lability and tunnel vision. Because of the uncontrolled nature of these spontaneous reports, a causal relationship to bu
spirone treatment has not been determined.
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How to Use
The recommended initial dose is 15 mg daily (5 mg 3 times a day). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maxim
um daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 to 30 mg per day were commonly employed.
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Why is this medication prescribed?
Buspirone (byoo-SPYE-rone) is used to treat certain anxiety disorders or to relieve the symptoms of anxiety. However, buspirone usually is not used for anxiety or tension caused by the stress of every
day life.
It is not known exactly how buspirone works to relieve the symptoms of anxiety. Buspirone is thought to work by decreasing the amount and actions of a chemical known as serotonin in
certain parts of the brain.
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What side effects can this medication cause?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your
doctor as soon as possible if any of the following side effects occur:
Chest pain; confusion; fast or pounding heartbeat; fever; incoordination; mental depression; muscle weakness; num
bness, tingling, pain, or weakness in hands or feet; skin rash or hives; stiffness of arms or legs; sore throat; uncontrolled movements of the body
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Before Using This Medicine
The presence of other medical problems may affect the use of buspirone. Make sure you tell your doctor if you have any other medical problems, especially:
- Kidney disease or
- Liver disease
ˇXBuspirone may be removed from your body more slowly, which may increase the chance of side effects. Your doctor may need to adjust your dose
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