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Special Wanring
CNS:
Dizziness, headache, drowsiness, lightheadedness, insomnia, fatigue, nervousness, decreased concentration, excitement, depression, confusion, nightmares/vivid dreams, anger/hostility. Infrequ
ently (<1%) depersonalization, noise intolerance, euphoria/feeling high, dissociative reaction, fear, loss of interest, dysphoria, hallucinations, seizures, suicidal thoughts. Rarely, slurred speech,
claustrophobia, cold intolerance, stupor, psychosis.
Neurologic:
Paresthesia, weakness, incoordination, tremor, numbness. Infrequently, muscle cramps and spasms, rigid/stiff muscles, involu
ntary movements, akathisia, slowed reaction time. Rarely, tingling of limbs, stiff neck, rigidity of jaw, ataxia.
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Possible food and drug interactions when taking this medication
In another study in normal volunteers, concomitant administration of buspirone and haloperidol resulted in increased serum haloperidol concentrations. The clinical significance of this finding is not
clear.
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How should this medicine be used?
Take BuSpar exactly as prescribed. Do not be discouraged if you feel no immediate effect. The full benefit of this drug may not be seen for 1 to 2 weeks after you start to take it.
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Description
Buspirone Hydrochloride is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. It is an agent that is not chemically or pharmacologically related to
the benzodiazepines (e.g. Valium, Xanax) barbituates, or other sedative/anti-anxiety drugs.
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Overdose
In clinical pharmacology trials, buspirone up to 400 mg/day was administered to healthy male volunteers. As this dose was approached, the following symptoms were observed in descending order of freque
ncy: drowsiness, ataxia, nausea and vomiting, dizziness, clammy feeling, difficulty thinking, feeling high, rushing sensation, gastric distress, headache, itching, miosis, hypotension, tremor, incoord
ination, insomnia and hallucinations. In a dose ranging study in acute psychotic patients, up to 2400 mg/day was administered. Dizziness, nausea and vomiting were the most common adverse effects. One
patient developed extrapyramidal symptoms at 600 mg/day.
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Precautions
Neuroendocrine Effects:
Single doses of 30 mg or higher of buspirone resulted in significantly elevated plasma prolactin and growth hormone concentrations in normal volunteers. No effect was seen
at lower doses. In another study, no such increases were observed after buspirone was administered in divided doses (10 mg t.i.d.) for 28 days.
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