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How should this medicine be used?
Buspirone comes as a tablet to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take buspirone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take buspirone even if you fe
el well. Do not stop taking buspirone without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must b
e taken regularly for a few weeks before its full effect is felt.
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What is this Drug
BUSPAR differs from typical benzodiazepines like Vallium or Xanax anti-anxiety medication in that it does not exert anti-seizure or muscle relaxant effects. It also lacks the prominent sedative effect
that is associated with benzodiazepines. In vitro studies have shown that BUSPAR has a high affinity for serotonin receptors (receptors in the brain that mediate arousal). BUSPAR has no significant a
ffinity for benzodiazepine receptors in the brain.
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Precautions
Neuroendocrine Effects:
Single doses of 30 mg or higher of buspirone resulted in significantly elevated plasma prolactin and growth hormone concentrations in normal volunteers. No effect was seen
at lower doses. In another study, no such increases were observed after buspirone was administered in divided doses (10 mg t.i.d.) for 28 days.
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What side effects may occur?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your
doctor as soon as possible if any of the following side effects occur:
Chest pain; confusion; fast or pounding heartbeat; fever; incoordination; mental depression; muscle weakness; num
bness, tingling, pain, or weakness in hands or feet; skin rash or hives; stiffness of arms or legs; sore throat; uncontrolled movements of the body
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Significant Interactions:
In a study in normal volunteers, no interaction of buspirone with amitriptyline was seen. A similar study with buspirone and diazepam showed an increase in the levels of nordiazepam.
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DRUG ABUSE AND DEPENDENCE :
In human and animal studies, BUSPAR has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence. Human volunteers wi
th a history of recreational drug or alcohol usage were studied in two double-blind clinical investigations. None of the subjects were able to distinguish between BUSPAR and placebo. In addition, stud
ies in monkeys, mice, and rats have indicated that BUSPAR lacks potential for abuse.
Although there is no direct evidence that BUSPAR causes physical dependence or drug-seeking behavior, it i
s difficult to predict from experiments the extent to which a CNS-active drug will be misused.
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