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Symptoms of overdose may include:
Bloody or black, tarry stools; continuing thirst; dizziness; drowsiness ; headache, severe or continuing; nausea and/or vomiting; shortness of breath; stomach pain; sudden decrease in the amou nt of urine; swelling of face, fingers, and/or lower legs; tightness in chest and/or wheezing; troubled breathing; unusual tiredness or weakness; vomiting of blood or material that looks like cof fee grounds; weight gain
- lack of energy
- drowsiness
- upset stomach
- vomiting
- stomach pain

How should this medicine be used?
You should continue to take CELEBREX as prescribed even when you are feeling better. CELEBREX can be taken with or without food. CELEBREX capsules come in 2 strengths: 100 mg and 200 mg.

In O steoarthritis, the recommended dose for CELEBREX is 200 mg a day. CELEBREX delivers 24-hour relief from a once-daily dose of 200 mg. Or if preferred, a dose of 100 mg twice a day is available.

In Rheumatoid Arthritis, the recommended dose for CELEBREX is 100 mg to 200 mg, twice a day. CELEBREX provides relief through the day and through the night.

What side effects can this medication cause?
Although side effects from celecoxib are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

- water retention
- upset stomach
- sto mach pain or cramps
- diarrhea
- gas
- headache

If you experience any of the following symptoms, call your doctor immediately:

- bloody vomit
- bloody diarrhea or black, tarry stools
- ringing in the ears
- blurred vision
- swelling of the hands, feet, ankles, or lower legs
- skin rash
- itching
- yellowing of the skin or eyes < br> - unexplained weight gain


What is this medicine
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis. It is the first of a new class of nonsteroidal anti-inflammatory drug s (NSAIDs) called "COX-2 inhibitors." Like older NSAIDs such as Motrin and Naprosyn, Celebrex is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unli ke the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Celebrex is therefore less likely to cau se the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.

Other medical problems
Celebrex can harm a developing baby if taken during the third trimester, and its safety earlier in pregnancy has not been confirmed. Take it during pregnancy only if you feel the risk is justified.
It's possible that Celebrex makes its way into breast milk (scientists aren't sure), and it could cause serious reactions in a nursing infant. If this drug is essential to your health, your do ctor may advise you to discontinue breastfeeding.

Significant Interactions:
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to c hange the dose, or other precautions may be necessary. When you are taking celecoxib, it is especially important that your health care professional know if you are taking any of the following:
- Aspirin or
- Fluconazole (e.g., Diflucan)¡XThe chance of serious side effects may be increased
- Lithium (e.g., Lithane)¡XHigher blood levels of celecoxib and an increased chance of si effects may occur


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