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is when you should be well on your way to a new lifestyle and ready to stop MERIDIA.

Appetite suppressants are not a substitute for proper diet. For maximum effects, this must be used in conjunction with a diet and exercise progra m.


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Description
Meridia helps the seriously overweight shed pounds and keep them off. It is especially recommended for those who in addition to being overweight have other health problems such as high blood pressure, diabetes, or high cholesterol. It is used in conjunction with a low-calorie diet.

Meridia works by boosting levels of certain chemical messengers in the nervous system, including serotonin, dopamine, and norepinephrine.

MERIDIA is a short-term drug that helps you to start losing weight and then keep on going when you are ready to carry on, on your own. Your body starts to build up a resistance to the effects of MERIDIA after a few weeks of treatment, which
Remember that Meridia must never be taken within 2 weeks of using an MAO inhibitor such as Marplan, Nardil, or Parnate. The combination could lead to serious, even fatal, overstimulation.

Am ong the many drugs that pose a potential problem are the following:
- Fentanyl (Duragesic)
- Fluoxetine (Prozac)
- Fluvoxamine (Luvox)
- Ketoconazole (Nizoral)
- Lithium (Eska lith, Lithobid)
- Meperidine (Demerol)
- Naratriptan (Amerge)
- Paroxetine (Paxil)
- Pentazocine (Talwin NX, Talacen)
- Sertraline (Zoloft)
- Stimulants such as amphetami nes, Dexedrine, Desoxyn, Adderall, Didrex, and Ionamin
- Sumatriptan (Imitrex)
- Tryptophan (L-Tryptophan)
- Venlafaxine (Effexor)
- Zolmitriptan (Zomig)

Proper Use of This Medicine
The recommended starting dose of MERIDIA is 10-milligrams administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after 4 weeks to a total of 15-mill igrams taken once daily. The 5-milligram dose should be reserved for those patients that do not tolerate the 10-milligram dose. Blood pressure and heart rate changes should betaken into consideration when making decisions regarding dose titration. Take this medication as prescribed. Do not take it more often or longer than directed. Use in combination with other appetite suppressant medicine is ge nerally not recommended.

What side effects may occur?
If you experience any of the following symptoms, call your doctor immediately:

- excessive sweating
- dilated pupils
- fast or irregular heartbeat
- vomiting
- extreme ex citement
- restlessness
- anxiety
- dizziness
- confusion
- loss of consciousness
- uncoordinated or abnormal movement
- flushing (feeling of warmth)
- difficul t speech
- eye pain
- tremor
- seizures
- chest pain
- excessive bruising or unusual bleeding
- rash
- hives

Cautions
Do not take Meridia while you are taking or within 2 weeks of taking medicines with monoamine oxidase (MAO) inhibitor activity , such as isocarboxazid (e.g., Marplan), phenelzine (e.g., Nardil), proca rbazine (e.g., Matulane), selegiline (e.g., Eldepryl), or tranylcypromine (e.g., Parnate). Do not take an MAO inhibitor within 2 weeks of taking Meridia. To do so may cause severe seizures, extremely high blood pressure, or a life-threatening adverse effect called the serotonin syndrome.

What special precautions should I follow?
Pregnancy¡XMeridia has not been studied in pregnant women. However, studies in animals have shown that Meridia causes birth defects when used in doses many times higher than the usual human dose. Befor e taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.


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