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Significant Interactions:
If Nexium is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nexium with the foll owing:

- Diazepam (Valium)
- Digoxin (Lanoxin)
- Iron salts (Ferro-Sequels)
- Ketoconazole (Nizoral)
- Warfarin (Coumadin)

There's no problem, however, with com bining antacids and Nexium; no unwanted interaction will result.

How should this medicine be used?
Nexium comes as delayed-release (long-acting) capsule to take by mouth. For inflamed esophagus and other conditions in which the stomach makes too much acid, one capsule is usually taken once a day fo r 4 to 8 weeks. It may be used for up to 6 months after your symptoms have improved.

For ulcers, one capsule is usually taken in combination with antibiotics once a day for 10 days.

Nexium should be swallowed whole and taken at least 1 hour before meals. Nexium may be taken with water, orange juice, apple juice, or yogurt.

Overdosage
Any medication taken in excess can have serious consequences. There have been some reports of Nexium overdoses. If you suspect an overdose, seek medical attention immediately.

Symptoms of Ne xium overdose may include:
- Blurred vision, confusion, drowsiness, dry mouth, flushing, headache, nausea, rapid heartbeat, sweating

What side effects may occur?
Rare side effects may include:
- Abnormal sense of smell, acne, allergic reaction, anemia, apathy, back pain, black stools, blood disorders, blood in urine, burping, change in bowel habits, chest pain, chills, confusion, constipation, coughing, cramps, difficulty breathing, difficulty swallowing, dizziness, dry mouth, ear infection, earache, enlarged abdomen, enlarged thyroid gland, eye infec tion, facial swelling, fast or irregular heartbeat, fatigue, fever, flu-like symptoms, flushing, frequent or increased urination, fungal infections, general feeling of illness, hernia, hiccups, high b lood pressure, hives, hot flushes, impotence, inability to sleep, increased appetite, indigestion,

Precautions Before Using This Medicine
Allergies¡XTell your doctor if you have ever had any unusual or allergic reaction to Nexium. Also tell your health care professional if you are allergic to any other substances, such as foods, preserv tives, or dyes.

Description
Nexium relieves heartburn and other symptoms caused by the backflow of stomach acid into the canal to the stomach (the esophagus)+m-a condition known as gastroesophageal reflux disease. It is also pre scribed to heal the damage (erosive esophagitis) that reflux disease can cause.

Prescribed in combination with the antibiotics Biaxin and Amoxil, Nexium is also used to treat the infection t hat causes most duodenal ulcers (ulcers occurring just beyond the exit from the stomach).

Like its sister drug Prilosec, Nexium works by reducing the production of stomach acid.


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