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Other medical problems
Children¡XPaxil has not be shown to be safe and effective in children or adolescents, 18 years of age or younger. Children may be especially sensitive to the effects of Paxil for the treatment of depr ssion. This may increase the chance of a child planning to commit suicide or attempting to commit suicide. Talk to your doctor about the risks and benefits of taking this medication.

Significant Interactions:
Renal Impairment: - Since paroxetine is extensively metabolized by the liver, excretion of unchanged drug in urine is a minor route of elimination. However, single dose pharmacokinetic studies in subj ects with clinically significant renal impairment suggest that plasma levels of paroxetine are elevated in such subjects. Paroxetine should therefore be used with caution and the dosage restricted to the lower end of the range in patients with clinically significant renal impairment.

Adverse Effects
Check with your doctor as soon as possible if any of the following side effects occur:

- Agitation; chest congestion; chest pain; chills; cold sweats; confusion; difficulty breathing; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; fast, pounding, or irregular heartbeat or pulse; muscle pain or weakness; skin rash

Side Effects of This Medicine
If you experience any of the following symptoms, call your doctor immediately:

- jaw, neck, and back muscle spasms
- slow or difficult speech
- shuffling walk
- persistent fin e tremor or inability to sit still
- fever, chills, sore throat, or flu-like symptoms
- difficulty breathing or swallowing
- severe skin rash
- yellowing of the skin or eyes
- irregular heartbeat

What is this medicine
Paxil is used to treat depression, obsessive-compulsive disorders, panic attacks, social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Paxil controlled-release (P axil CR) is used to treat depression and panic attacks. Paxil is in a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of certain natural substances in the brain.

How should you take this medication?
You may have to take Paxil for several weeks before you begin to feel better. Your doctor should check your progress at regular visits during this time. Also, if you are taking Paxil for depression, y ou will probably need to continue taking it for at least 6 months to help prevent the depression from returning.

If you are taking the oral suspension form of Paxil, shake the bottle well bef ore measuring each dose. Use a small measuring cup or a measuring spoon to measure each dose. The teaspoons and tablespoons that are used for serving and eating food do not measure exact amounts.


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