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Other Medicines
Renal Impairment: - Since paroxetine is extensively metabolized by the liver, excretion of unchanged drug in urine is a minor route of elimination. However, single dose pharmacokinetic studies in subj
ects with clinically significant renal impairment suggest that plasma levels of paroxetine are elevated in such subjects. Paroxetine should therefore be used with caution and the dosage restricted to
the lower end of the range in patients with clinically significant renal impairment.
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Special warnings about this medication
Paxil should be used cautiously by people with a history of manic disorders and those with high pressure in the eyes (glaucoma).
If you have a history of seizures, make sure your doctor know
s about it. Paxil should be used with caution in this situation. If you develop seizures once therapy has begun, the drug should be discontinued.
If you have a disease or condition that affe
cts your metabolism or blood circulation, make sure your doctor is aware of it. Paxil should be used cautiously in this situation.
Paxil may impair your judgment, thinking, or motor skills.
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How should you take this medication?
Paxil has not been shown to add to the effects of alcohol. However, use of alcohol is not recommended in patients who are taking Paxil.
Paxil may cause some people to become drowsy or have bl
urred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see clearly.
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What side effects can this medication cause?
Less common side effects may include:
- Abdominal pain, abnormal dreams, abnormal vision, agitation, altered taste sensation, blurred vision, burning or tingling sensation, drugged feeling, emoti
onal instability, headache, increased appetite, infection, itching, joint pain, muscle tenderness or weakness, pounding heartbeat, rash, ringing in ears, sinus inflammation, tightness in throat, twitc
hing, upset stomach, urinary disorders, vomiting, weight gain, vertigo, yawning
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Special Wanring
Commonly Observed: - The most commonly observed adverse experiences associated with the use of paroxetine and not seen at an equivalent incidence among placebo treated patients were: Nausea, somnolenc
e, sweating, tremor, asthenia, dizziness, dry mouth, insomnia and male sexual dysfunction (primarily ejaculatory delay).
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Symptoms of overdose
Overdose attempts have been reported with paroxetine; up to 850 mg alone and in combination with other agents. In cases where paroxetine was used alone, no deaths have occurred and recovery was medica
lly uneventful.
Symptoms of overdosage with paroxetine include nausea, vomiting, tremor, dilated pupils, dry mouth and irritability. There are no reports of ECG abnormalities, coma or convul
sions following overdosage with paroxetine alone.
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