The Personality Pill. Prozac
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Symptoms of overdose may include:
Establish and maintain an airway; ensure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be con
sidered in treating overdose.
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Adverse Effects
Gastrointestinal:
Frequent: Nausea, disturbances of appetite, diarrhea.
Infrequent: Vomiting, stomatitis, dysphagia, eructation, esophagitis, gastritis, gingivitis, glossitis, melena, th
irst, abnormal liver function tests.
Rare: Bloody diarrhea, hematemesis, gastrointestinal hemorrhage, duodenal ulcer, stomach ulcer, mouth ulceration, hyperchlorhydria, colitis, enteritis, c
holecystitis, cholelithiasis, hepatitis, hepatomegaly, liver tenderness, jaundice, increased salivation, salivary gland enlargement, tongue discoloration, fecal incontinence, pancreatitis.
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Other Medicines
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui
ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th
is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena
zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
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Proper Use of This Medicine
Prozac comes as a capsule, tablet, and liquid to take by mouth. It is usually taken once or twice a day and may be taken with or without food. Follow the directions on your prescription label carefull
y, and ask your doctor or pharmacist to explain any part you do not understand. Take Prozac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Continue to take Prozac even if you feel well. Do not stop taking Prozac without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want
to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.
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Precautions
Concomitant Illness: - Clinical experience with fluoxetine in patients with concomitant systemic illness is limited and it should be used cautiously in such patients, especially those with diseases or
conditions that could affect metabolism or hemodynamic responses
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Possible food and drug interactions when taking this medication
When you are taking Prozac, it is especially important that your health care professional know if you are taking any of the following:
- Astemizole (e.g., Hismanal)¡XHigher blood levels of a
temizole may occur, which increases the chance of having a very serious change in the rhythm of your heartbeat
- Buspirone (e.g., BuSpar) or
- Bromocriptine (e.g., Parlodel) or
- Dextro
methorphan (cough medicine) or
- Levodopa (e.g., Sinemet) or
- Lithium (e.g., Eskalith) or
- Meperidine (e.g., Demerol) or
- Nefazodone (e.g., Serzone) or
- Pentazocine (e.g.,
Talwin) or
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