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Precautions Before Using This Medicine
Pregnancy¡XOne study of babies whose mothers had taken Prozac while they were pregnant found some problems in the babies, such as premature birth, jitteriness, and trouble in breathing or nursing. How
ver, four other studies did not find any problems in babies or young children whose mothers had taken Prozac while they were pregnant. Tell your doctor if you are pregnant or if you may become pregnan
t while you are taking this medicine.
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What side effects may occur?
In children and adolescents, less common side effects may also include:
- Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of
elation and/or rapid thoughts), nosebleeds, personality changes, and thirst
A wide variety of other very rare reactions have been reported during Prozac therapy. If you develop any new or un
explained symptoms, tell your doctor without delay.
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Warning
Concomitant Illness: - Clinical experience with fluoxetine in patients with concomitant systemic illness is limited and it should be used cautiously in such patients, especially those with diseases or
conditions that could affect metabolism or hemodynamic responses
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How should you take this medication?
Prozac comes as a capsule, tablet, and liquid to take by mouth. It is usually taken once or twice a day and may be taken with or without food. Follow the directions on your prescription label carefull
y, and ask your doctor or pharmacist to explain any part you do not understand. Take Prozac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Prozac oral liquid comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper. Dilute the liquid in 4 ounces (120 ml) of water, apple j
uice, or Gatorade just before taking it.
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Possible food and drug interactions
P450 isozyme (IID6): - Like other selective serotonin reuptake inhibitors, fluoxetine inhibits the specific hepatic cytochrome P450 isozyme (IID6) which is responsible for the metabolism of debrisoqui
ne and sparteine. Although the clinical significance of this effect has not been established, inhibition of IID6 may lead to elevated plasma levels of co-administered drugs which are metabolized by th
is isozyme. Drugs metabolized by cytochrome P450IID6 include the tricyclic antidepressants (e.g., nortriptyline, amitriptyline, imipramine, and desipramine), phenothiazine neuroleptics (e.g., perphena
zine and thioridazine), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
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Why is this drug prescribed?
Prozac is used to treat mental depression. It is also used to treat obsessive-compulsive disorder, bulimia nervosa, and premenstrual dysphoric disorder.
Prozac also may be used for other cond
itions as determined by your doctor.
Prozac belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the act
ivity of a chemical called serotonin in the brain.
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