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Significant Interactions:
If Xenical is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Xenical with the fo llowing:

- Cyclosporine (Neoral and Sandimmune)
- Warfarin (Coumadin)

Diet Program
Follow the diet program your doctor has given you. You should evenly divide your daily intake of fat, carbohydrates, and protein over three main meals. If Xenical is taken with a meal very high in fat (30% total daily calories from fat), you may experience more side effects from the medication.

Xenical blocks your body's uptake of some fat-soluble vitamins and beta carotene. Therefore, wh en you use Xenical you should take a daily multivitamin supplement that contains vitamins A, E, K, and beta-carotene. Take the vitamin once a day, 2 hours before or 2 hours after taking Xenical, or ta ke the vitamin at bedtime.

Side Effects
More common side effects may include:
- Abdominal discomfort or pain, anxiety, arthritis, back pain, diarrhea, dizziness, earache, fatigue, fatty or oily stools, fecal urgency or incontinence, fl u, gas with fecal discharge, gum problems, headache, increased defecation, menstrual problems, muscle pain, nausea, oily discharge, rectal discomfort or pain, respiratory tract infections, skin rash, sleep problems, tooth problems, urinary tract infections, vaginal inflammation, vomiting

Less common side effects may include:
- Dry skin, ear/nose/throat problems, joint disorders
< br> Side effects that usually occur after the first year of treatment with Xenical include: depression, leg pain, swollen feet, and tendonitis.

Symptoms of overdose
The results of a massive overdose of Xenical are unknown, although the drug seems relatively harmless. However, any medication taken in excess can have serious consequences. If you suspect an overdose , seek medical attention.

Before Using This Medicine
Breast-feedingˇXIt is not known whether Xenical passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers w o are taking this medicine and who wish to breast-feed should discuss this with their doctor.

How should this medicine be used?
Xenical comes as a capsule to take by mouth. It is usually taken three times a day with each main meal that contains fat. Each time you take Xenical, your meal should contain no more than about 30% of calories from fat. Take Xenical during or up to 1 hour after a meal. If a meal is missed or does not have fat, you may skip your dose. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Xenical is in a class of drugs called lipase inhibitors. It works in your intestines, where it blocks some of the fat you eat from being absorbed and disgested. This undigested fat is then removed in your bowel movements (BM).


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