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Zovirax (Generic)
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How to Use
If you are using tablets, capsules, or liquid, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals.

If you are using ointment, apply it as soon as you remember and apply further doses at your regular interval (e.g., every 3 hours) until you go to bed.

However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of either the ointment or oral medication to make up for a missed one.

Why is this drug prescribed?
If you are sensitive to or have ever had an allergic reaction to Zovirax or similar drugs, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced.

Other Medicines
If Zovirax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zovirax with the fo llowing:

- Cyclosporine (Sandimmune, Neoral)
- Interferon (Roferon-A)
- Probenecid (Benemid)
- Zidovudine (Retrovir)

Proper Use of This Medicine
If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

What special precautions should I follow?
Children¡XStudies on this medicine have been done only in adult patients, and there is no specific information comparing use of topical Zovirax in children with use in other age groups.

Side Effects
Parenteral:
1. Renal toxicity; precipitation of Zovirax crystals can occur in renal tubules if the maximum solubility of free Zovirax (2.5mg/ml at 37?C in water) is exceeded or if the drug is give n by bolus injection. Serum creatinine and BUN rise and creatinine clearance decreases.
2. Encephalopathic changes: Approximately 1% of patients receiving IV Zovirax manifested encephalopathic cha nges characterized by lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures or coma.
3. Other: transient elevation of serum creatinine; rash or hives; diaphoresis; hematur ia; hypotension; headache and nausea; thrombocytosis.


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