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Cautions
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the needs of your condition and to help avoid unwanted effects.

Do not take Zyban within 14 days of taking an MAO inhibitor.

Zyban is sold under different brand names for different uses. If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o ne prescription for Zyban at a time.

Significant Interactions:
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:

- Tricyclic antidepressants (amitriptyline [e.g., Elavil ], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) or
-
- Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegi line [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X Do not take Zyban while you are taking or within 14 days of taking an MAO inhibitor

Overdosage

- difficulty breathing or swallowing
- dizziness
- fainting
- shakiness
- sweating
- confusion
- blurred vision
- seizure
- seeing things or hearing voices that do not exist (hallucinating)
- loss of consciousness
- rapid or pounding hearbeat
- blurred vision
- lightheadedness
- confusion
- lack of energy
- upset stoma ch
- jitteriness

Side Effects of This Medicine
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyban.
< br> The most common side effects are:
Dry mouth and sleeplessness
These are generally mild and usually disappear after a few weeks. If you have difficulty sleeping, avoid taking Zyban close t o bedtime and ask your doctor about reducing your dosage.

More common side effects may include:
Abdominal pain, abnormal dreams, anxiety, constipation, diarrhea, disturbed concentration , dizziness, joint pain, increased cough, itching, nasal inflammation, nausea, nervousness, rash, sore throat

How to Use
Zyban comes as a tablet to take by mouth. It is usually taken one to three times a day and may be taken with or without food. Do not crush, chew, or divide Wellbutrin SR or Zyban tablets. Follow the d irections on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Zyban exactly as directed.

Continue to take Zyban even if you feel well. Do not stop taking Zyban without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Before Taking This Medicine
Stop taking Zyban and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out wi th itchy eruptions. These are warning signs of a potentially severe allergic reaction.

If you have a liver or kidney condition, make sure the doctor is aware of it. Your dosage may need to b e reduced. (If you have severe cirrhosis of the liver, your dosage must be reduced.) Also make certain the doctor knows about any heart condition you may have.

Zyban can interfere with your driving ability. Don't drive or operate dangerous machinery until you are certain of the drug's effect on you.


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