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How should you take this medication?
Treatment with this drug begins while you are still smoking. Zyban needs about a week to reach an effective level in your body; so to improve your chance of success, you should not attempt to quit unt
il the second week of treatment. Set a firm date for quitting. If you are still smoking after that date, your odds of breaking the habit will be worse. You should keep taking Zyban for 7 to 12 weeks.
You can use nicotine patches along with Zyban. However, combining the two treatments can raise your blood pressure, so it's important to tell your doctor if you plan to use both. Do not smok
e while using a patch, because too much nicotine can cause serious side effects.
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Precautions Before Using This Medicine
Allergies¡XTell your doctor if you have ever had any unusual or allergic reaction to Zyban. Also tell your health care professional if you are allergic to any other substances, such as foods, preserva
ives, or dyes.
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Cautions
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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Side Effects
Side effects from Zyban are common:
- drowsiness
- weakness or tiredness
- excitement or anxiety
- dry mouth
- insomnia
- nightmares
- change in appetite or wei
ght
Tell your doctor if any of these symptoms are severe or do not go away:
- frequent urination
- difficulty urinating
- constipation
- blurred vision
- change
in sex drive or ability
- excessive sweating
- headaches
If you experience any of the following symptoms, call your doctor immediately:
- seizures or tremors
- loss
of coordination
- fever
- severe skin rash
- itching
- hives
- chest pain
- shortness of breath
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Overdose
Quitting smoking, with or without Zyban treatment, could change the way your body metabolizes certain drugs, for example, theophylline and warfarin (Coumadin). Make sure your doctor knows all the pres
cription and over-the-counter medicines you're taking.
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Why is this drug prescribed?
3 Zyban (Wellbutrin SRR, ZybanR)
Approved indication: 1) Symptomatic relief of depressive illness (effectiveness for use > 8 weeks has not been evaluated in controlled trials). 2) As an aid to smo
king cessation (6-7 weeks).
Mechanism of action: Zyban is chemically related to sympathomimetic drugs and unrelated to other antidepressants. It blocks reuptake of noradrenaline and dopamine,
but the mechanism for its clinical effects is unknown.
Pharmacokinetics: It is extensively metabolized by the liver to at least 3 active metabolites. Half-life of parent drug and active meta
bolites is 20 to 37 hrs.
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