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Safety Issues Affecting Chinese Herbs: The Case Of Ma-Huang
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In the United States, ephedra and ephedrine are sold in health food stores under a variety of brand names. Ephedrine is widely used for weight loss, as an energy booster, and to enhance athletic perfo rmance. These products often contain other stimulants, such as caffeine, which may have synergistic effects and increase the potential for adverse effects. Ephedra is often touted as the "herbal fen-p hen."

Recently, the FDA has called for strict limits on the recommended dose and proposed new labeling of products containing ephedrine. The FDA¡¦s proposal would prohibit the marketing of dietary supplement s containing 8 milligrams or more of ephedrine alkaloids per serving, with warnings against using more than 24 mg per day and using the product for more than SEVEN DAYS. Any such product with claims e ncouraging short-term excessive intake would be required to list the following statement on its label: ¡§Taking more than the recommended serving may result in heart attack, stroke, seizure or death.¡¨

What is ephedrine? Ephedrine (e-fed¡¦rin) a-methylamino-l phenyl-l propanol, is an alkaloid from the leaves of Ephededra equisetina, E. Sinica, and other species (family Gnetaceae). It is also called E phedra & Ma Huang, the plant source for the Alkaloid ephedrine. Indigenous to China, India and parts of SoutheastAsia . Products containing ephedrine extracts have according to the FDA, caused hundred s of illnesses, including heart attacks, seizures, strokes and even 15 reported deaths. They are amphetamine-like compounds with powerful and potentially lethal stimulant effects on the central nervou s system and the heart.

Ephedrine is an adrenergic drug that works by stimulating alpha
-and beta receptors thus causing the release of norepinephrine.
-Alpha and beta receptors exist in the sympathetic nervous system,
-(fight or flight) and stimulation causes increased heart rate,
-bronchodilation, and vasoconstriction.

Ephedrine is a naturally occuring central nervous system stimulant obtained
-from the plant _Ephedra equisetina_. It is now also produced by chemical
-synthesis, the synthetic product being mark eted in the form of its salt,
-ephedrine sulfate; it occurs as a white crystalline powder with a bitter
-taste, soluble in water and very soluble in alcohol. Ephedrine is closely
-related in structure to methamphetamine, although its CNS actions are much
-less potent and also longer-acting than those of the amphetamines. Its
-peripheral stimulant actions are similar to but less powe rful than those of
-epinephrine (also called adrenaline), a hormone produced in the body by the
-adrenal glands.

Ephedrine is the active ingredient in many diet pills and supplements. Many use the name "thermo", "lean" or "fat burner." Brand names include, Metabolife, MeTrim, Herbalife, Adiphen, Thermalean, Lipo drene, Zymax, Genicil, Patent Lean, Thermoslim, Ultra Lipo Lean, Trim Life, Hydroxy Cut, Xenadrine, Herbal Phen-Fen, Shapefast, Thermoburn, Thyro-slim, Trim Spa, Natural Trim, Thermo-Lift and many oth ers.


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